Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Carnitine o-octanoyltransferase is a p53 target that promotes oxidative metabolism and cell survival following nutrient starvation.

The Journal of biological chemistry - 1 Jul 2023

Sanford Jack D, Franklin Derek, Grois Gabriella A, Jin Aiwen, Zhang Yanping

Abstract excerpt

Whereas it is known that p53 broadly regulates cell metabolism, the specific activities that mediate this regulation remain partially understood. Here, we identified carnitine o-octanoyltransferase (CROT) as a p53 transactivation target that is upregulated by cellular stresses in a p53-dependent manner. CROT is a peroxisomal enzyme catalyzing very long-chain fatty acids conversion to medium chain fatty acids that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Carnitine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Growth Processes

Share to Cell Respiration

Share to Fatty Acids

Share to Nutrients

Share to Peroxisomes

Share to Response Elements

Source

Open in PubMed Open full text

Identifiers

PMID: 37307919
DOI: 10.1016/j.jbc.2023.104908
PMCID: PMC10339192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Carnitine o-octanoyltransferase is a p53 target that promotes oxidative metabolism and cell survival following nutrient starvation.PMID 37307919Read ↗

Exploring the significance of fatty acid metabolism reprogramming in the pathogenesis of cancer and anticancer therapySemantic proximity Read ↗

TAp63-regulated oncogenic long non-coding RNA-8 ( <i>TROLL-8</i> ) regulates human breast cancer progression through CPT1A-mediated fatty acid oxidationSemantic proximity Read ↗

CPT1A loss disrupts BCAA metabolism to confer therapeutic vulnerability in TP53-mutated liver cancer.Semantic proximity Read ↗

Mitochondrial Genetic Disorders: Cell Signaling and Pharmacological TherapiesSemantic proximity Read ↗

Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ–p53–p21 signaling pathwaySemantic proximity Read ↗

Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancerSemantic proximity Read ↗

Upregulation of energy metabolism-related, p53-target TIGAR and SCO2 in HuH-7 cells with p53 mutation by geranylgeranoic acid treatment.Semantic proximity Read ↗

p53 and TIGAR promote redox control to protect against metabolic dysfunction-associated steatohepatitisSemantic proximity Read ↗

Resveratrol-Induced Changes in MicroRNA Expression in Primary Human Fibroblasts Harboring Carnitine-Palmitoyl Transferase-2 Gene Mutation, Leading to Fatty Acid Oxidation Deficiency.Semantic proximity Read ↗

Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice.Semantic proximity Read ↗

Exogenous L-carnitine a meliorated burn-induced cellular and mitochondrial injuries of hepatocytes via recovering CPT1 activitySemantic proximity Read ↗

Functional partitioning of lipoic acid decouples cellular abundance from mitochondrial utilizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.