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Article

The Impact of Germline Alterations in Appendiceal Adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Jul 2023

Foote Michael B, Walch Henry, Kemel Yelena, Vakiani Efsevia, Johannet Paul, Sheehan Margaret, Chatila Walid, Chung Sebastian, Nash Garrett M, Maio Anna, Shia Jinru, Mandelker Diana, Berger Michael, Schultz Nikolaus, Diaz Luis A, Cercek Andrea, Stadler Zsofia K

Abstract excerpt

PURPOSE: More than 10% of assessed patients with appendiceal adenocarcinoma have a pathogenic (P) or likely pathogenic (LP) germline variant, including genes implicated in heritable gastrointestinal cancer syndromes, such as Lynch syndrome. We defined the clinical and molecular impact of heritable alterations in appendiceal adenocarcinoma to evaluate the need for dedicated appendiceal screening and prevention...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37289003
DOI: 10.1158/1078-0432.CCR-22-3956
PMCID: PMC10642170

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