Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix.

doi:10.1038/modpathol.2017.184

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Article

Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2018

Jesinghaus Moritz, Konukiewitz Björn, Foersch Sebastian, Stenzinger Albrecht, Steiger Katja, Muckenhuber Alexander, Groß Claudia, Mollenhauer Martin, Roth Wilfried, Detlefsen Sönke, Weichert Wilko, Klöppel Günter, Pfarr Nicole, Schlitter Anna Melissa

Abstract excerpt

The appendix gives rise to goblet cell carcinoids, which represent special carcinomas with distinct biological and histological features. Their genetic background and molecular relationship to colorectal adenocarcinoma is largely unknown. We therefore performed a next-generation sequencing analysis of 25 appendiceal carcinomas including 11 goblet cell carcinoids, 7 adenocarcinomas ex-goblet cell carcinoid, and 7...

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PMID: 29327707
DOI: 10.1038/modpathol.2017.184

Genes

APC
KRAS
CTNNA1
CTNNB1
EGFR
NOTCH1
NRAS
TRRAP

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