Priority index for asthma (PIA): In silico discovery of shared and distinct drug targets for adult- and childhood-onset disease.

Abstract excerpt

Asthma is a chronic disease that is caused by a combination of genetic risks and environmental triggers and can affect both adults and children. Genome-wide association studies have revealed partly distinct genetic architectures for its two age-of-onset subtypes (namely, adult-onset and childhood-onset). We reason that identifying shared and distinct drug targets between these subtypes may inform the development...

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