Article
The effect of haploidentical hematopoietic stem cell transplantation on comutations based on next-generation sequencing in adult acute myeloid leukemia patients with the FLT3-ITD mutation.
Hematological oncology - 1 Oct 2023
Tang Feifei, Zhao Xiaosu, Ruan Guorui, Jiang Qian, Jiang Hao, Xu Lanping, Wang Yu, Zhang Xiaohui, Liu Kaiyan, Huang Xiaojun
Abstract excerpt
According to the 2022 European LeukemiaNet, all acute myeloid leukemia (AML) cases with FLT3-ITD mutations are now categorized as intermediate risk irrespective of the FLT3-ITD allelic ratio or concurrent presence of NPM1 mutation. However, whether other next-generation sequencing (NGS) comutation genes can add layers to FLT3-ITD and whether the poor outcomes of FLT3-ITD comutations can be overcome by...
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