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KRAS G12C mutation and risk of disease recurrence in stage I surgically resected lung adenocarcinoma.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2023

Gallina F T, Marinelli D, Melis E, Forcella D, Taje R, Buglioni S, Visca P, Torchia A, Cecere F L, Botticelli A, Santini D, Ciliberto G, Cappuzzo F, Facciolo F

Abstract excerpt

KRAS G12C mutations are found in about 12-13% of LUAD samples and it is unclear whether they are associated with worse survival outcomes in resected, stage I LUAD. We assessed whether KRAS-G12C mutated tumours had worse DFS when compared to KRAS-nonG12C mutated tumours and to KRAS wild-type tumours in a cohort of resected, stage I LUAD (IRE cohort). We then leveraged on publicly available datasets (TCGA-LUAD,...

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PMID: 37253296
DOI: 10.1016/j.lungcan.2023.107254

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