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Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank.

Osteoarthritis and cartilage - 1 Oct 2023

Hollis B, Chatzigeorgiou C, Southam L, Hatzikotoulas K, Kluzek S, Williams A, Zeggini E, Jostins-Dean L, Watt F E

Abstract excerpt

OBJECTIVE: Acute knee injury is associated with post-traumatic OA (PTOA). Very little is known about the genome-wide associations of PTOA when compared with idiopathic OA (iOA). Our objective was to describe the development of knee OA after a knee injury and its genetic associations in UK Biobank (UKB). DESIGN: Clinically significant structural knee injuries in those ≤50 years were identified from electronic...

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PMID: 37247657
DOI: 10.1016/j.joca.2023.05.012

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