Article
The genetic contribution to severe post-traumatic osteoarthritis.
Annals of the rheumatic diseases - 1 Oct 2013
Valdes Ana M, Doherty Sally A, Muir Kenneth R, Wheeler Margaret, Maciewicz Rose A, Zhang Weiya, Doherty Michael
Abstract excerpt
OBJECTIVE: to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement. METHODS: A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12...
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