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The causal effects of age at menarche, age at first live birth, and estradiol levels on systemic lupus erythematosus: A two-sample Mendelian randomization analysis.

Lupus - 1 Jul 2023

Zhang Yongbin, Fang Yuxuan, Xu Nan, Tian Longlong, Min Xingxing, Chen Guiyu, Dai Tiantian, Liu Nianxing, Wang Xuanhan, Rao Yujun, Li Guoqing

Abstract excerpt

OBJECTIVES: To determine whether age at menarche (AAM), age at first live birth (AFB), and estradiol levels are causally correlated with the development of systemic lupus erythematosus (SLE). METHODS: A two-sample Mendelian randomization (MR) analysis was performed after data was collected from a dataset of genome-wide association studies (GWASs) related to SLE (as outcome), and from open access databases to find...

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PMID: 37246529
DOI: 10.1177/09612033231180358

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