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Article

Mendelian Randomization and Transcriptome-Wide Association Analysis Identified Genes That Were Pleiotropically Associated with Intraocular Pressure.

Genes - 30 Apr 2023

Yang Zhikun, Zhang Zhewei, Zhu Yining, Yuan Guangwei, Yang Jingyun, Yu Weihong

Abstract excerpt

BACKGROUND: Intraocular pressure (IOP) is a major modifiable risk factor for glaucoma. However, the mechanisms underlying the controlling of IOP remain to be elucidated. OBJECTIVE: To prioritize genes that are pleiotropically associated with IOP. METHODS: We adopted a two-sample Mendelian randomization method, named summary-based Mendelian randomization (SMR), to examine the pleiotropic effect of gene expression...

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Identifiers

PMID: 37239387
DOI: 10.3390/genes14051027
PMCID: PMC10218376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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