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Article

Hierarchical association of COPD to principal genetic components of biological systems.

PloS one - 1 Jan 2023

Carlin Daniel E, Larsen Simon J, Sirupurapu Vikram, Cho Michael H, Silverman Edwin K, Baumbach Jan, Ideker Trey

Abstract excerpt

Many disease-causing genetic variants converge on common biological functions and pathways. Precisely how to incorporate pathway knowledge in genetic association studies is not yet clear, however. Previous approaches employ a two-step approach, in which a regular association test is first perform...

Topics

Humans
Genetic Predisposition to Disease
Pulmonary Disease, Chronic Obstructive
Genetic Association Studies
Genome-Wide Association Study
Polymorphism, Single Nucleotide

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37228113
DOI: 10.1371/journal.pone.0286064
PMCID: PMC10212185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-37228113-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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