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SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis

9 Mar 2022

Abstract excerpt

The SARS-CoV-2 Omicron variant has rapidly displaced the Delta variant and spread across the world. The Omicron variant harbors over 60 mutations, and 15 of the mutations are located in the receptor-binding domain (RBD). 1 Compared with parental virus and previous variants, the Omicron variant is characterized by decreased hospitalization rates and less severe disease in patients. 2 However, how the Omicron...

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PMID: 35264568
DOI: 10.1038/s41392-022-00941-z

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