Grad-seq identifies KhpB as a global RNA-binding protein inClostridioides difficilethat regulates toxin production

Abstract excerpt

ABSTRACT Much of our current knowledge about cellular RNA–protein complexes in bacteria is derived from analyses in gram-negative model organisms, with the discovery of RNA-binding proteins (RBPs) generally lagging behind in Gram-positive species. Here, we have applied Grad-seq analysis of native RNA–protein complexes to a major Gram-positive human pathogen, Clostridioides difficile, whose RNA biology remains...

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