Article
Gut Microbiota Taxon-Dependent Transformation of Microglial M1/M2 Phenotypes Underlying Mechanisms of Spatial Learning and Memory Impairment after Chronic Methamphetamine Exposure.
Microbiology spectrum - 15 Jun 2023
Wu Yulong, Dong Zhouyan, Jiang Xinze, Qu Lei, Zhou Wei, Sun Xu, Hou Jiangshan, Xu Hongmei, Cheng Mei
Abstract excerpt
Methamphetamine (METH) exposure may lead to cognitive impairment. Currently, evidence suggests that METH exposure alters the configuration of the gut microbiota. However, the role and mechanism of the gut microbiota in cognitive impairment after METH exposure are still largely unknown. Here, we investigated the impact of the gut microbiota on the phenotype status of microglia (microglial phenotypes M1 and...
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