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Neuroprotective effect of engineered Clostridium butyricum‐pMTL007‐GLP ‐1 on Parkinson's disease mice models via promoting mitophagy

17 Mar 2023

Abstract excerpt

Abstract Parkinson's disease (PD) is a common neurodegenerative disease with limited treatment and no cure, hence, broadening PD drug spectrum is of great significance. At present, engineered microorganisms are attracting increasing attention. In this study, we constructed an engineered strain of Clostridium butyricum ‐GLP‐1, a C. butyricum (a probiotic) that consistently expresses glucagon‐like peptide‐1 (GLP‐1,...

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PMID: 37206220
DOI: 10.1002/btm2.10505

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