Article
<i>Faecalibacterium prausnitzii</i> , depleted in the Parkinson’s disease microbiome, improves motor deficits in α-synuclein overexpressing mice
2025-09-21
Abstract excerpt
Gut microbiome composition is altered in Parkinson’s disease (PD), a neurodegenerative disorder characterized by motor dysfunction and frequently accompanied by gastrointestinal (GI) symptoms. Notably, microbial taxa with anti-inflammatory properties are consistently depleted in PD patients compared to controls. To explore whether specific gut bacteria may be disease-protective, we assembled a microbial consortium...
Topics
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- Autophagy in Disease and Therapy
- Botulinum Toxin and Related Neurological Disorders
- Clostridium difficile and Clostridium perfringens research
- Dysphagia Assessment and Management
- Gastrointestinal motility and disorders
- Gut microbiota and health
- Neurological diseases and metabolism
- Parkinson's Disease Mechanisms and Treatments
Identifiers and source
- Literature Corpus work
- 30af4bb2-8a5d-5855-9996-fa162aa80f28
- DOI
- 10.1101/2025.09.18.677192
