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Article

The clinical value of proneural, classical and mesenchymal protein signatures in WHO 2021 adult-type diffuse lower-grade gliomas.

PloS one - 1 Jan 2023

Dénes Anna, Bontell Thomas Olsson, Barchéus Hanna, Vega Sandra Ferreyra, Carén Helena, Lindskog Cecilia, Jakola Asgeir S, Smits Anja

Abstract excerpt

OBJECTIVES: Accumulating evidence shows that mesenchymal transition of glioblastomas is associated with a more aggressive course of disease and therapy resistance. In WHO2021-defined adult-type diffuse gliomas of lower grade (dLGG), the transition of the tumor phenotype over time, has not been studied. Most efforts to correlate proneural, classical or mesenchymal phenotype with outcome in dLGG were made prior to...

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PMID: 37192181
DOI: 10.1371/journal.pone.0285732
PMCID: PMC10187920

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