Article
Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis.
Gut microbes - 1 Jan 2000
Martinez-Gili Laura, Pechlivanis Alexandros, McDonald Julie A K, Begum Sofina, Badrock Jonathan, Dyson Jessica K, Jones Rebecca, Hirschfield Gideon, Ryder Stephen D, Sandford Richard, Rushbrook Simon, Thorburn Douglas, Taylor-Robinson Simon D, Crossey Mary M E, Marchesi Julian R, Mells George, Holmes Elaine, Jones David
Abstract excerpt
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease with ursodeoxycholic acid (UDCA) as first-line treatment. Poor response to UDCA is associated with a higher risk of progressing to cirrhosis, but the underlying mechanisms are unclear. UDCA modulates the composition of primary and bacterial-derived bile acids (BAs). We characterized the phenotypic response to UDCA based on BA and bacterial...
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