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Biological Significance of microRNA Biomarkers in ALS—Innocent Bystanders or Disease Culprits?

11 Jun 2019

Abstract excerpt

MicroRNAs (miRNAs) represent potential biomarkers for neurodegenerative disorders including amyotrophic lateral sclerosis (ALS). However, whether expression changes of individual miRNAs are simply an indication of cellular dysfunction and degeneration, or promote functional changes in target gene expression relevant to disease pathogenesis, is unclear. Here we used bioinformatics to test the hypothesis that...

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PMID: 31244752
DOI: 10.3389/fneur.2019.00578

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