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Article

Matrix Metalloproteinases Contribute to the Calcification Phenotype in Pseudoxanthoma Elasticum.

Biomolecules - 12 Apr 2023

Plümers Ricarda, Lindenkamp Christopher, Osterhage Michel Robin, Knabbe Cornelius, Hendig Doris

Abstract excerpt

Ectopic calcification and dysregulated extracellular matrix remodeling are prominent hallmarks of the complex heterogenous pathobiochemistry of pseudoxanthoma elasticum (PXE). The disease arises from mutations in ABCC6, an ATP-binding cassette transporter expressed predominantly in the liver. Neither its substrate nor the mechanisms by which it contributes to PXE are completely understood. The fibroblasts...

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Identifiers

PMID: 37189419
DOI: 10.3390/biom13040672
PMCID: PMC10135689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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