Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Perturbation of specific pro-mineralizing signalling pathways in human and murine pseudoxanthoma elasticum

29 Apr 2014

Abstract excerpt

BACKGROUND: Pseudoxanthoma elasticum (PXE) is characterized by skin (papular lesions), ocular (subretinal neovascularisation) and cardiovascular manifestations (peripheral artery disease), due to mineralization and fragmentation of elastic fibres in the extracellular matrix (ECM). Caused by mutations in the ABCC6 gene, the mechanisms underlying this disease remain unknown. The knowledge on the molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dermatological and Skeletal Disorders
Share to Parathyroid Disorders and Treatments
Share to Sphingolipid Metabolism and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24775865
DOI: 10.1186/1750-1172-9-66

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Perturbation of specific pro-mineralizing signalling pathways in human and murine pseudoxanthoma elasticumPMID 24775865Read ↗

Matrix Metalloproteinases Contribute to the Calcification Phenotype in Pseudoxanthoma Elasticum.Semantic proximity Read ↗

Pseudoxanthoma elasticum, the paradigm of heritable ectopic mineralization disorders - can diet help?Semantic proximity Read ↗

Correlation of systemic involvement and presence of pathological skin calcification assessed by ex vivo nonlinear microscopy in Pseudoxanthoma elasticum.Semantic proximity Read ↗

Pseudoxanthoma elasticum - Genetics, pathophysiology, and clinical presentation.Semantic proximity Read ↗

Pseudoxanthoma elasticum and skin: Clinical manifestations, histopathology, pathomechanism, perspectives of treatmentSemantic proximity Read ↗

Atorvastatin counteracts aberrant soft tissue mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6⁻/⁻).Semantic proximity Read ↗

Fibroblast involvement in soft connective tissue calcificationSemantic proximity Read ↗

Pseudoxanthoma elasticumSemantic proximity Read ↗

Pseudoxanthoma Elasticum-Like Changes:Associations- and Underlying Mechanisms.Semantic proximity Read ↗

Insights into Pathomechanisms and Treatment Development in Heritable Ectopic Mineralization Disorders: Summary of the PXE International Biennial Research Symposium-2016.Semantic proximity Read ↗

An update on the ocular phenotype in patients with pseudoxanthoma elasticumSemantic proximity Read ↗

Pseudoxanthoma elasticum: progress in diagnostics and research towards treatment : Summary of the 2010 PXE International Research Meeting.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.