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Article

Serum factors from pseudoxanthoma elasticum patients alter elastic fiber formation in vitro.

The Journal of investigative dermatology - 1 Jul 2006

Le Saux Olivier, Bunda Severa, VanWart Christopher M, Douet Vanessa, Got Laurence, Martin Ludovic, Hinek Aleksander

Abstract excerpt

Pseudoxanthoma elasticum (PXE) is a heritable disorder mainly characterized by calcified elastic fibers in cutaneous, ocular, and vascular tissues. PXE is caused by mutations in ABCC6, a gene encoding an ABC transporter predominantly expressed in liver and kidneys. The functional relationship between ABCC6 and elastic fiber calcification is unknown. We speculated that ABCC6 deficiency in PXE patients induces a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16543900
DOI: 10.1038/sj.jid.5700201
PMCID: PMC5540375

Genes

ABCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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