Article
Hypercholesterolemia induced by spontaneous oligogenic mutations in rhesus macaques (Macaca mulatta).
Journal of medical primatology - 1 Aug 2023
Takenaka Akiko, Suzuki Juri, Tanaka Hiroyuki, Hibino Kumiko, Kamanaka Yoshiro, Nakamura Shin, Mitsunaga Fusako, Kawamoto Yoshi, Morimoto Mayumi, Aisu Seitaro, Natsume Takayoshi
Abstract excerpt
BACKGROUND: A rhesus macaque with the fourth highest plasma cholesterol (CH) levels of 501 breeding macaques was identified 22 years ago. Seven offspring with gene mutations causing hypercholesterolemia were obtained. METHODS: Activity of low-density lipoprotein receptor (LDLR), plasma CH levels and mRNA expression levels of LDLR were measured after administration of 0.1% (0.27 mg/kcal) or 0.3% CH. RESULTS:...
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