Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the Alternative Complement Pathway With Iptacopan to Treat IgA Nephropathy: Design and Rationale of the APPLAUSE-IgAN Study

9 Feb 2023

Abstract excerpt

Introduction: Targeting the alternative complement pathway (AP) is an attractive therapeutic strategy because of its role in immunoglobulin A nephropathy (IgAN) pathophysiology. Iptacopan (LNP023), a proximal complement inhibitor that specifically binds to factor B and inhibits the AP, reduced proteinuria and attenuated AP activation in a Phase 2 study of patients with IgAN, thereby supporting the rationale for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Kidney Injury Research
Share to Complement system in diseases
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37180505
DOI: 10.1016/j.ekir.2023.01.041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the Alternative Complement Pathway With Iptacopan to Treat IgA Nephropathy: Design and Rationale of the APPLAUSE-IgAN StudyPMID 37180505Read ↗

Challenges in IgA Nephropathy Management: An Era of Complement InhibitionSemantic proximity Read ↗

Targeting complement in IgA nephropathySemantic proximity Read ↗

The complement system in IgAN: mechanistic context for therapeutic opportunitiesSemantic proximity Read ↗

Kidney diseasesSemantic proximity Read ↗

IgA nephropathy: new insights into the role of complementSemantic proximity Read ↗

IgA Nephropathy.Semantic proximity Read ↗

C3 Glomerulopathy: A Current Perspective in an Evolving LandscapeSemantic proximity Read ↗

Complement and Complement Targeting Therapies in Glomerular DiseasesSemantic proximity Read ↗

Comprehensive Analysis of IgA Nephropathy Causal Factors in Plasma Proteins, Immune Cell Types, and Immune Cell Traits.Semantic proximity Read ↗

C3 glomerulopathy: a kidney disease mediated by alternative pathway deregulationSemantic proximity Read ↗

Real-World Effectiveness and Safety of Avacopan in ANCA-Associated Vasculitis: A Systematic Literature Review and Meta-analysisSemantic proximity Read ↗

[IgA nephropathy--pathogenesis, pathophysiology, and therapy].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.