Article
SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2022
McGrath Marisa E, Xue Yong, Dillen Carly, Oldfield Lauren, Assad-Garcia N, Zaveri Jayshree, Singh Natasha, Baracco Lauren, Taylor Louis J, Vashee Sanjay, Frieman Matthew B
Abstract excerpt
The ongoing COVID-19 pandemic is a major public health crisis. Despite the development and deployment of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pandemic persists. The continued spread of the virus is largely driven by the emergence of viral variants, which can evade the current vaccines through mutations in the spike protein. Although these differences in spike are...
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