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The cytokine receptor CRLF3 is a human neuroprotective EV-3 (Epo) receptor

6 Apr 2023

Abstract excerpt

The evolutionary conserved orphan cytokine receptor-like factor 3 (CRLF3) has been implicated in human disease, vertebrate hematopoiesis and insect neuroprotection. While its specific functions are elusive, experimental evidence points toward a general role in cell homeostasis. Erythropoietin (Epo) is a major regulator of vertebrate hematopoiesis and a general cytoprotective cytokine. Erythropoietic functions...

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PMID: 37168680
DOI: 10.3389/fnmol.2023.1154509

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