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Article

FGFR2-activating mutations disrupt cell polarity to potentiate migration and invasion in endometrial cancer cell models.

Journal of cell science - 10 Aug 2018

Stehbens Samantha J, Ju Robert J, Adams Mark N, Perry Samuel R, Haass Nikolas K, Bryant David M, Pollock Pamela M

Abstract excerpt

Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases that control a diverse range of biological processes during development and in adult tissues. We recently reported that somatic FGFR2 mutations are associated with shorter survival in endometrial cancer. However, little is known about how these FGFR2 mutations contribute to endometrial cancer metastasis. Here, we report that...

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Source

Identifiers

PMID: 30002137
DOI: 10.1242/jcs.213678

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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