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Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging

6 May 2023

Abstract excerpt

Abstract Background Ultraviolet A (UVA) irradiation can lead to skin damage and premature skin aging known as photoaging. This work found that UVA irradiation caused an imbalance between dermal matrix synthesis and degradation through the aberrant upregulation of transgelin (TAGLN) and studied the underlying molecular mechanism. Results Co-immunoprecipitation and proximal ligation assay results showed that TAGLN...

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Share to Genomics, phytochemicals, and oxidative stress
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PMID: 37149635
DOI: 10.1186/s13578-023-01029-z

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