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Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target

26 Sept 2011

Abstract excerpt

Medulloblastomas are the most common malignant brain tumors in children. They express high levels of COX-2 and produce PGE2, which stimulates tumor cell proliferation. Human cytomegalovirus (HCMV) is prevalent in the human population and encodes proteins that provide immune evasion strategies and promote oncogenic transformation and oncomodulation. In particular, HCMV induces COX-2 expression; STAT3...

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PMID: 21946257
DOI: 10.1172/jci57147

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