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Construction of a Dengue NanoLuc Reporter Virus for In Vivo Live Imaging in Mice

9 Jun 2022

Abstract excerpt

Since the first isolation in 1943, the dengue virus (DENV) has spread throughout the world, but effective antiviral drugs or vaccines are still not available. To provide a more stable reporter DENV for vaccine development and antiviral drug screening, we constructed a reporter DENV containing the NanoLuc reporter gene, which was inserted into the 5' untranslated region and capsid junction region, enabling rapid...

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PMID: 35746724
DOI: 10.3390/v14061253

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