Article
Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits.
Current biology : CB - 11 Mar 2008
Groszer Matthias, Keays David A, Deacon Robert M J, de Bono Joseph P, Prasad-Mulcare Shweta, Gaub Simone, Baum Muriel G, French Catherine A, Nicod Jérôme, Coventry Julie A, Enard Wolfgang, Fray Martin, Brown Steve D M, Nolan Patrick M, Pääbo Svante, Channon Keith M, Costa Rui M, Eilers Jens, Ehret Günter, Rawlins J Nicholas P, Fisher Simon E
Abstract excerpt
The most well-described example of an inherited speech and language disorder is that observed in the multigenerational KE family, caused by a heterozygous missense mutation in the FOXP2 gene. Affected individuals are characterized by deficits in the learning and production of complex orofacial motor sequences underlying fluent speech and display impaired linguistic processing for both spoken and written language....
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