Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits.

doi:10.1016/j.cub.2008.01.060

Article

Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits.

Current biology : CB - 11 Mar 2008

Groszer Matthias, Keays David A, Deacon Robert M J, de Bono Joseph P, Prasad-Mulcare Shweta, Gaub Simone, Baum Muriel G, French Catherine A, Nicod Jérôme, Coventry Julie A, Enard Wolfgang, Fray Martin, Brown Steve D M, Nolan Patrick M, Pääbo Svante, Channon Keith M, Costa Rui M, Eilers Jens, Ehret Günter, Rawlins J Nicholas P, Fisher Simon E

Abstract excerpt

The most well-described example of an inherited speech and language disorder is that observed in the multigenerational KE family, caused by a heterozygous missense mutation in the FOXP2 gene. Affected individuals are characterized by deficits in the learning and production of complex orofacial mo...

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Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits.

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