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Article

Synergistic action of carvedilol and clomiphene in mitigating the behavioral phenotypes of letrozole-model of PCOS rats by modulating the NRF2/NFKB pathway.

Life sciences - 1 Jul 2023

Akintoye Olabode Oluwadare, Ajibare Ayodeji Johnson, Oriyomi Isaac Adeola, Olofinbiyi Babatunde Ajayi, Yusuf Grace Oyiza, Afuye Damilola Christanah, Babalola Temitope Kabirat, Faturoti Oluwadamilola Esther, Oludipe Seun, Owoyele Victor Bamidele

Abstract excerpt

INTRODUCTION: Psychiatric and cognitive impairment has been observed in premenopausal women with a hormonal disorder called polycystic ovary syndrome (PCOS). This study aimed to explore the possibility of combining pharmacological agents: Carvedilol and Clomiphene citrate, with antiestrogenic, antioxidant and anti-inflammatory properties in letrozole-induced PCOS rats. METHODS: PCOS was induced in rats by the...

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Identifiers

PMID: 37127183
DOI: 10.1016/j.lfs.2023.121737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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