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Ovarian epigenetics modifications following lifestyle interventions by exercise and alternate-day feeding in letrozole-induced PCOS rats

15 Jul 2025

Abstract excerpt

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women, often associated with changes in emotional well-being, oxidative stress, and epigenetic modifications. While lifestyle changes are the primary treatment, their roles in ovarian epigenetics in PCOS remain unknown. This study investigates the impact of treadmill exercise and alternate-day feeding (ADF), either individually or...

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PMID: 40664896
DOI: 10.1038/s41598-025-09264-9

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