Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adaptive molecular evolution of the Major Histocompatibility Complex genes, DRA and DQA, in the genus Equus.

BMC evolutionary biology - 18 May 2011

Kamath Pauline L, Getz Wayne M

Abstract excerpt

BACKGROUND: Major Histocompatibility Complex (MHC) genes are central to vertebrate immune response and are believed to be under balancing selection by pathogens. This hypothesis has been supported by observations of extremely high polymorphism, elevated nonsynonymous to synonymous base pair substitution rates and trans-species polymorphisms at these loci. In equids, the organization and variability of this gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Sequence
Share to Equidae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Genes, MHC Class II

Share to Molecular Sequence Data

Share to Phylogeny

Share to Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 21592397
DOI: 10.1186/1471-2148-11-128
PMCID: PMC3126738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adaptive molecular evolution of the Major Histocompatibility Complex genes, DRA and DQA, in the genus Equus.PMID 21592397Read ↗

Polymorphism and selection in the major histocompatibility complex DRA and DQA genes in the family Equidae.Semantic proximity Read ↗

Extensive polymorphism of the major histocompatibility complex DRA gene in Balkan donkeys: perspectives on selection and genealogy.Semantic proximity Read ↗

Polymorphism at expressed DQ and DR loci in five common equine MHC haplotypes.Semantic proximity Read ↗

Newly identified variability of the antigen binding site coding sequences of the equine major histocompatibility complex class I and class II genes.Semantic proximity Read ↗

Unraveling the effects of selection and demography on immune gene variation in free-ranging plains zebra (Equus quagga) populations.Semantic proximity Read ↗

Molecular phylogeny of extant equids and effects of ancestral polymorphism in resolving species-level phylogenies.Semantic proximity Read ↗

DNA sequence analysis of serologically detected ELA class II haplotypes at the equine DQ beta locus.Semantic proximity Read ↗

Genetic diversity of the class II major histocompatibility DRA locus in European, Asiatic and African domestic donkeys.Semantic proximity Read ↗

Positive selection in the SLC11A1 gene in the family Equidae.Semantic proximity Read ↗

Major histocompatibility complex variation and evolution at a single, expressed DQA locus in two genera of elephants.Semantic proximity Read ↗

Reassessing the evolutionary history of ass-like equids: insights from patterns of genetic variation in contemporary extant populations.Semantic proximity Read ↗

Extensive polymorphism and geographical variation at a positively selected MHC class II B gene of the lesser kestrel (Falco naumanni).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.