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Article

The impact of PIK3CA mutations and PTEN expression on the effect of neoadjuvant therapy for postmenopausal luminal breast cancer patients.

BMC cancer - 27 Apr 2023

Hayama Shouko, Nakamura Rikiya, Ishige Takayuki, Sangai Takafumi, Sakakibara Masahiro, Fujimoto Hiroshi, Ishigami Emi, Masuda Takahito, Nakagawa Ayako, Teranaka Ryotaro, Ota Satoshi, Itoga Sakae, Yamamoto Naohito, Nagashima Takeshi, Otsuka Masayuki

Abstract excerpt

BACKGROUND: There is pressing needs to find the biomarker in the selection of neoadjuvant therapy in postmenopausal luminal breast cancer patients. We examined the hypothesis that PIK3CA mutations and low phosphatase and tensin homolog (PTEN) expression affect the response to neoadjuvant therapy and prognosis in postmenopausal luminal breast cancer patients. METHODS: Postmenopausal patients with estrogen...

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Identifiers

PMID: 37106324
DOI: 10.1186/s12885-023-10853-y
PMCID: PMC10134571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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