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Matrisome gene-based subclassification of patients with liver fibrosis identifies clinical and molecular heterogeneities

26 Apr 2023

Abstract excerpt

BACKGROUND AIMS: Excessive deposition and crosslinking of extracellular matrix increases liver density and stiffness, promotes fibrogenesis, and increases resistance to fibrinolysis. An emerging therapeutic opportunity in liver fibrosis is to target the composition of the extracellular matrix or block pathogenic communication with surrounding cells. However, the type and extent of extracellular changes triggering...

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PMID: 37098756
DOI: 10.1097/hep.0000000000000423

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