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Article

Generation of Rh D‐negative blood using CRISPR / Cas9

25 Apr 2023

Abstract excerpt

Abstract Blood supply shortages, especially the shortage of rare blood types, threaten the current medical system. Research on stem cells has shed light on in vitro blood cell manufacturing. The in vitro production of universal red blood cells (RBCs) from induced pluripotent stem cells (iPSCs) has become the focus of transfusion medicine. To obtain O‐type Rh D‐negative blood, we developed O‐type Rh D‐negative...

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PMID: 37096780
DOI: 10.1111/cpr.13486

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