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Article

TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication

21 Apr 2023

Abstract excerpt

Coronaviruses are positive-strand RNA viruses with 3' polyadenylated genomes and subgenomic transcripts. The lengths of the viral poly(A) tails change during infection by mechanisms that remain poorly understood. Here, we use a splint-ligation method to measure the poly(A) tail length and poly(A) terminal uridylation and guanylation of the mouse hepatitis virus (MHV) RNAs. Upon infection of 17-CL1 cells with MHV,...

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PMID: 37085578
DOI: 10.1038/s42003-023-04814-1

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