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In vivo gene editing of T-cells in lymph nodes for enhanced cancer immunotherapy

25 Nov 2024

Abstract excerpt

Immune checkpoint blockade (ICB) therapy, while promising for cancer treatment, faces challenges like unexpected side effects and limited objective responses. Here, we develop an in vivo gene-editing strategy for improving ICB cancer therapy in a lastingly effective manner. The approach uses a conductive hydrogel-based electroporation system to enable nucleofection of programmed cell death protein 1 (PD1)...

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PMID: 39587061
DOI: 10.1038/s41467-024-54292-0

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