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Concurrent IDH1 and IDH2 mutations in glioblastoma: A case report

3 Apr 2023

Abstract excerpt

Isocitrate dehydrogenase (IDH) mutations are cornerstone diagnostic features in glioma classification. IDH mutations are typically characterized by mutually exclusive amino acid substitutions in the genes encoding for the IDH1 and the IDH2 enzyme isoforms. We report our institutional case of a diffuse astrocytoma with progression to secondary glioblastoma and concurrent IDH1/IDH2 mutations. A 49-year-old male...

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PMID: 37077830
DOI: 10.3389/fonc.2023.1071792

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