Article
Frequency and mutational spectrum of PIK3CA gene mutations in breast cancer patients: Largest and first report from Lebanon.
Gene - 30 Jun 2023
Hamadeh Lama N, Farhat Lama, Hilal Lamia, Assi Hazem, Nasr Fadi, Chahine Georges, Kattan Joseph, Farhat Fadi, Kourie Hampig, El Hachem Georges, Ghosn Marwan, El Saghir Nagi, Chamseddine Nabil, Finianos Antoine, Ghanem Hady, Younes Ahmad, Gerges Dany Abi, Temraz Sally, Haidar Mohammad, Nabhan Therese, Chamseddine Ali, Tfayli Arafat, Zaatari Ghazi, Mahfouz Rami
Abstract excerpt
The PIK3CA pathway is one of the most frequently altered pathways in human cancers, especially in breast cancer with approximately 40% of HR+/HER2- advanced breast cancer cases exhibiting mutations in the PIK3CA gene. While the mutations can occur across the entire gene, the most common are observed in exon 9 corresponding to the helical domain, and in exon 20 encompassing the kinase domain. This study...
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