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Toward Corneal Limbus In Vitro Model: Regulation of hPSC-LSC Phenotype by Matrix Stiffness and Topography During Cell Differentiation Process.

Advanced healthcare materials - 1 Nov 2023

Kauppila Maija, Mörö Anni, Valle-Delgado Juan José, Ihalainen Teemu, Sukki Lassi, Puistola Paula, Kallio Pasi, Ilmarinen Tanja, Österberg Monika, Skottman Heli

Abstract excerpt

A functional limbal epithelial stem cells (LSC) niche is a vital element in the regular renewal of the corneal epithelium by LSCs and maintenance of good vision. However, little is known about its unique structure and mechanical properties on LSC regulation, creating a significant gap in development of LSC-based therapies. Herein, the effect of mechanical and architectural elements of the niche on human...

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PMID: 37449943
DOI: 10.1002/adhm.202301396
PMCID: PMC11468526

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