Article
New insights into the clinical characteristics of SETD2-mutated acute myeloid leukaemia.
British journal of haematology - 1 Jul 2023
Zhang Xiang, Wang Ziwei, Sun Jiewen, Liu Lixia, Qin Jiayue, Huang Aijie, Yang Min, Lou Yinjun, Tang Gusheng, Mao Liping, Qian Jiejin, Wei Juying, Mai Wenyuan, Meng Haitao, Yang Jianmin, Tong Hongyan, Wang Jianmin, Yu Wenjuan, Ni Xiong, Jin Jie
Abstract excerpt
As reported, SETD2 is recurrently mutated in acute myeloid leukaemia (AML), but knowledge about the specifics is limited. We enrolled 530 consecutive newly diagnosed AML patients in our study, and we analysed the distribution pattern and prognostic role of SETD2 mutation in AML. SETD2 mutation was found to affect 6.3% of AML patients, and it frequently co-occurred with IDH2, NRAS and CEBPA mutations....
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