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Article

Association of genetically-predicted placental gene expression with adult blood pressure traits.

Journal of hypertension - 1 Jun 2023

Hellwege Jacklyn N, Stallings Sarah C, Piekos Jacqueline A, Jasper Elizabeth A, Aronoff David M, Edwards Todd L, Velez Edwards Digna R

Abstract excerpt

OBJECTIVE: Blood pressure is a complex, polygenic trait, and the need to identify prehypertensive risks and new gene targets for blood pressure control therapies or prevention continues. We hypothesize a developmental origins model of blood pressure traits through the life course where the placenta is a conduit mediating genomic and nongenomic transmission of disease risk. Genetic control of placental gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37016918
DOI: 10.1097/HJH.0000000000003427
PMCID: PMC10287061

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