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Onset of infectiousness explains differences in transmissibility across Mycobacterium tuberculosis lineages.

Epidemics - 1 Jun 2025

Windels Etthel M, Valenzuela Agüí Cecilia, de Jong Bouke C, Meehan Conor J, Loiseau Chloé, Goig Galo A, Zwyer Michaela, Borrell Sonia, Brites Daniela, Gagneux Sebastien, Stadler Tanja

Abstract excerpt

Mycobacterium tuberculosis complex (MTBC) lineages show substantial variability in virulence, but the epidemiological consequences of this variability have not been studied in detail. Here, we aimed for a lineage-specific epidemiological characterization by applying phylodynamic models to genomic data from different countries, representing the most abundant MTBC lineages. Our results suggest that all lineages are...

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PMID: 40118009
DOI: 10.1016/j.epidem.2025.100821

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