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Article

Fc-mediated pan-sarbecovirus protection after alphavirus vector vaccination

30 Mar 2023

Abstract excerpt

Group 2B β-coronaviruses (sarbecoviruses) have caused regional and global epidemics in modern history. Here, we evaluate the mechanisms of cross-sarbecovirus protective immunity, currently less clear yet important for pan-sarbecovirus vaccine development, using a panel of alphavirus-vectored vaccines covering bat to human strains. While vaccination does not prevent virus replication, it protects against lethal...

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PMID: 37000623
DOI: 10.1016/j.celrep.2023.112326

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