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SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity

17 Jan 2022

Abstract excerpt

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VOCs) exhibit escape from neutralizing antibodies, causing concern about vaccine effectiveness. However, while non-neutralizing cytotoxic functions of antibodies are associated with improved disease outcome and vaccine protection, Fc effector function escape from VOCs is poorly defined. Furthermore, whether VOCs trigger Fc functions...

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PMID: 35233544
DOI: 10.1016/j.xcrm.2022.100510

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