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Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high-grade serous ovarian cancer.

Basic & clinical pharmacology & toxicology - 1 Jun 2023

Deng Feng, Laasik Maren, Salminen Liina, Lapatto Lauri, Huhtinen Kaisa, Li Yilin, Hautaniemi Sampsa, Hynninen Johanna, Niemi Mikko, Lehtonen Rainer

Abstract excerpt

Adverse effects are the major limiting factors in combinatorial chemotherapies. To identify genetic associations in ovarian cancer chemotherapy-induced toxicities and therapy outcomes, we examined a cohort of 101 patients receiving carboplatin-paclitaxel treatment with advanced high-grade serous ovarian cancers. Based on literature and database searches, we selected 19 candidate polymorphisms, designed a...

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PMID: 36988399
DOI: 10.1111/bcpt.13866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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