Article
EULAR study group on 'MHC-I-opathy': identifying disease-overarching mechanisms across disciplines and borders.
Annals of the rheumatic diseases - 1 Jul 2023
Kuiper Jonas Jw, Prinz Jörg C, Stratikos Efstratios, Kuśnierczyk Piotr, Arakawa Akiko, Springer Sebastian, Mintoff Dillon, Padjen Ivan, Shumnalieva Russka, Vural Seçil, Kötter Ina, van de Sande Marleen G, Boyvat Ayşe, de Boer Joke H, Bertsias George, de Vries Niek, Krieckaert Charlotte Lm, Leal Inês, Vidovič Valentinčič Nataša, Tugal-Tutkun Ilknur, El Khaldi Ahanach Hanane, Costantino Félicie, Glatigny Simon, Mrazovac Zimak Danijela, Lötscher Fabian, Kerstens Floor G, Bakula Marija, Viera Sousa Elsa, Böhm Peter, Bosman Kees, Kenna Tony J, Powis Simon J, Breban Maxime, Gul Ahmet, Bowes John, Lories Rik Ju, Nowatzky Johannes, Wolbink Gerrit Jan, McGonagle Dennis G, Turkstra Franktien
Abstract excerpt
The 'MHC-I (major histocompatibility complex class I)-opathy' concept describes a family of inflammatory conditions with overlapping clinical manifestations and a strong genetic link to the MHC-I antigen presentation pathway. Classical MHC-I-opathies such as spondyloarthritis, Behçet's disease, psoriasis and birdshot uveitis are widely recognised for their strong association with certain MHC-I alleles and gene...
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