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Development of innovative multi-epitope mRNA vaccine against central nervous system tuberculosis using in silico approaches

6 Sept 2024

Abstract excerpt

Tuberculosis(TB) of the Central nervous system (CNS) is a rare and highly destructive disease. The emergence of drug resistance has increased treatment difficulty, leaving the Bacillus Calmette-Guérin (BCG) vaccine as the only licensed preventative immunization available. This study focused on identifying the epitopes of PknD (Rv0931c) and Rv0986 from Mycobacterium tuberculosis(Mtb) strain H37Rv using an in...

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PMID: 39240891
DOI: 10.1371/journal.pone.0307877

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